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Finally, using a format that makes it possible toprint on a single page if desired, we have includedpornographically attractive figures throughout thebook, which have already proven popular with manystudents and are likely to do so again. We havealso established a consistent format for electronicpresentation that makes it easy to tailor the book forpressing or Web use.

We continue to believe that the best way to teach immunologyis to stimulate students' interest and to encourage themto explore the vast world of imaginative ideas, con-ceivably even to develop their own ideas. One ofthe ways we do this is to introduce special topicsearly in the course and then develop them throughoutthe course and emphasize their importance.Another is to look to the future, and present some ofthe most innovative new advances in immunology.Only by encouraging students to think without fear of failure can they eventually developintellectually honest and efficient judgement as a clinician,researcher, and teacher.

Modern immunology began in the late nineteenth centurywith the recognition that organisms produce chemicals(antibodies) that are able to kill microbes that are notthemselves pathogenic. However, it was only in the1920s that the idea that antibodyresponses are not random but have definite struc-tures was firmly established. Subsequent advancesin technology have made it possible to map theorganism's immune response, achieving a prote-nomic picture of the immune system.

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